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KMID : 0378119950220020523
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Chungnam Medical Journal
1995 Volume.22 No. 2 p.523 ~ p.528
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Effects of Midazolam on Tracheal Smooth Muscle and Antagonistic Effects of Flumazenil
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윤석화
신용섭/손수창/이원형/김혜자/최세진
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Abstract
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Midazolam have been used widely as adjuvants in both regional and general anesthesia and in high risk patients in the intensive care unit. In the present study we evaluated the effect of midazolam and antagonistic effect of flumazenil on isolated
rat
tracheal preparations mounted for recording isometric contractile force. Trachea smooth muscle were contracted with acetylcholine (10E-E, Ach) and potassium chloride (40mM KC1). Midazolam 5×10E-6M and 5×10E-5M produced dose-dependent relaxation
and
flumazenil (3.2×10E-7M), central antagonist of benzodiazepine, pretreatment had no significant change midazolaminduced relaxation.
Midazolam probably did not relax airway smooth muscle by activatong central benzodiazepine receptors, as flumazenil did not block the concentration-related relaxation of midazolam.
Our study suggests that flumazenil may be used safety for asthmatic patients who have been with midazolam, as flumazenil did not antagonize airway relaxatio elicited by midazolam.
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KEYWORD
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